E3泛素蛋白连接酶ZNRF2 (EC 2.3.2.27) (Protein Ells2) (环指蛋白202) (RING型E3泛素转移酶ZNRF2) (锌/RING指蛋白2)
E3泛素蛋白连接酶ZNRF2 (EC 2.3.2.27) (Protein Ells2) (环指蛋白202) (RING型E3泛素转移酶ZNRF2) (锌/RING指蛋白2)
Q8NHG8功能描述
E3 ubiquitin-protein ligase，在神经元传递和可塑性的建立及维持中发挥作用。泛素化Na(+)/K(+) ATPase alpha-1亚基/ATP1A1，从而影响其内吞和/或降解 (PubMed:22797923)。也作为氨基酸激活mTORC1的正调节因子，作用于V-ATPase和Rag-GTPases的上游 (PubMed:27244671)。反过来，mTOR的磷酸化导致其被靶向至细胞质从而受到抑制，形成一种自我调节的反馈机制 (PubMed:27244671)。 {ECO:0000269|PubMed:14561866, ECO:0000269|PubMed:22797923, ECO:0000269|PubMed:27244671}。
组织特异性
Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney.
亚细胞定位
Endosome membrane
关键词