ZMIZ1 Q9ULJ6

含MIZ结构域锌指蛋白1 (PIAS样蛋白Zimp10) (视黄酸诱导蛋白17)

蛋白质信息 (UniProt)

含MIZ结构域锌指蛋白1 (PIAS样蛋白Zimp10) (视黄酸诱导蛋白17)

Q9ULJ6

功能描述

作为转录共激活因子。增强AR的配体依赖性转录活性并促进AR的SUMO化。AR活性的刺激依赖于SUMO化 (PubMed:14609956, PubMed:26522984)。还作为TGF-beta信号通路中的转录共激活因子，通过增强SMAD3/SMAD4转录复合物的活性发挥作用 (PubMed:16777850)。参与包括MYC在内的部分NOTCH1靶基因的转录激活。参与胸腺细胞和T细胞发育 (By similarity)。参与发育中大脑皮层锥体神经元有丝分裂后定位的调节 (PubMed:30639322)。 {ECO:0000250|UniProtKB:Q6P1E1, ECO:0000269|PubMed:14609956, ECO:0000269|PubMed:16777850, ECO:0000269|PubMed:26522984, ECO:0000269|PubMed:30639322}。

组织特异性

Expressed most abundantly in ovary and, at lower levels, in prostate, spleen and testis. Weak expression, if any, in thymus, small intestine, colon and peripheral blood leukocytes.

亚细胞定位

Nucleus, nucleoplasm

关键词

3D-structure Activator Alternative splicing Cytoplasm Disease variant Intellectual disability Isopeptide bond Metal-binding Nucleus Proteomics identification

外部链接

UniProt: Q9ULJ6

NCBI Gene

GeneCards