ZG16B Q96DA0

胰腺腺癌上调因子 (酶原颗粒蛋白16同源物B)

蛋白质信息 (UniProt)

胰腺腺癌上调因子 (酶原颗粒蛋白16同源物B)

Q96DA0

功能描述

作为一种凝集素发挥作用，结合选择性的共生牙菌斑细菌，如 vestibularis 链球菌。通过捕获共生微生物并利用粘蛋白辅助清除机制调节其生长，有助于维持口腔微生物组的稳态 (PubMed:37216558)。在胰腺肿瘤进展和转移中发挥重要作用 (PubMed:19302292, PubMed:36232715)。通过 TLR4/MyD88/NF-kappaB 信号通路促进胰腺癌细胞迁移和侵袭，而不涉及 TLR4/TRIF 通路 (PubMed:36232715)。 {ECO:0000269|PubMed:19302292, ECO:0000269|PubMed:36232715, ECO:0000269|PubMed:37216558}。

组织特异性

Highly expressed in pancreatic cancer tissues (at protein levels). Also expressed in the placenta and colon and ovarian cancer tumors (PubMed:19302292). Highly expressed in salivary glands, in submandibular and sublingual glands (PubMed:33207190).

亚细胞定位

Secreted

关键词

3D-structure Cell membrane Cytoplasm Direct protein sequencing Glycoprotein Lectin Membrane Proteomics identification Reference proteome Secreted

外部链接

UniProt: Q96DA0

NCBI Gene

GeneCards