YWHAQ P27348

14-3-3蛋白θ (14-3-3蛋白T细胞) (14-3-3蛋白tau) (蛋白HS1)

功能描述

衔接蛋白，参与多种通用及特异信号通路的调节。结合大量伙伴，通常通过识别磷酸丝氨酸或磷酸苏氨酸基序。结合通常导致结合伙伴活性的调节。负向调节PDPK1的激酶活性。{ECO:0000269|PubMed:12177059}。

组织特异性

Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement.

亚细胞定位

Cytoplasm. Note=In neurons, axonally transported to the nerve terminals.