YTHDC2 Q9H6S0

3'-5' RNA解旋酶YTHDC2 (EC 3.6.4.13) (含YTH结构域蛋白2) (hYTHDC2)

蛋白质信息 (UniProt)

3'-5' RNA解旋酶YTHDC2 (EC 3.6.4.13) (含YTH结构域蛋白2) (hYTHDC2)

Q9H6S0

功能描述

3'-5' RNA解旋酶，通过促进干细胞从有丝分裂向减数分裂的转变，在雄性和雌性生殖系中发挥关键作用 (PubMed:26318451, PubMed:29033321, PubMed:29970596)。特异性识别并结合含有N6-甲基腺苷 (m6A) 的RNA，这种修饰存在于mRNA内部位点及某些非编码RNA中，在RNA加工效率和稳定性方面发挥作用 (PubMed:26318451, PubMed:29033321)。通过调节含m6A RNA的水平，对于确保生殖系减数分裂程序的顺利进行至关重要 (By similarity)。通过结合并促进含m6A mRNA的降解发挥作用：此过程需要3'-5' RNA解旋酶活性，RNA降解可能由XRN1核糖核酸外切酶介导 (PubMed:29033321)。精子发生和卵子发生均需要 (By similarity)。 {ECO:0000250|UniProtKB:B2RR83, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:29033321, ECO:0000269|PubMed:29970596}。

组织特异性

Expressed in testis (PubMed:29087293). Not detected in spermatogonia next to the tubule wall but is strongly expressed in spermatocytes, suggesting that it is up-regulated in germ cells upon entry into meiosis (PubMed:29087293).

亚细胞定位

Cytoplasm

关键词

3D-structure ANK repeat ATP-binding Cytoplasm Differentiation Helicase Hydrolase Meiosis Nucleotide-binding Oogenesis

外部链接

UniProt: Q9H6S0

NCBI Gene

GeneCards