YBX2 Q9Y2T7

Y-box结合蛋白2 (Contrin) (DNA结合蛋白C) (Dbpc) (生殖细胞特异性Y-box结合蛋白) (MSY2同源物)

功能描述

信使核糖核蛋白颗粒(mRNPs)的主要成分。参与生殖细胞mRNA稳定性和/或翻译的调节。结合Y-box共有启动子元件。以不依赖序列的方式高亲和力结合全长mRNA。以低亲和力和有限的序列特异性结合包含共有位点5'-UCCAUCA-3'的短RNA序列。其与母源mRNA的结合是其细胞质滞留所必需的。可能在细胞核中标记特定的mRNA（那些从Y-box启动子转录的mRNA）以进行细胞质储存，从而将转录与mRNA储存/翻译延迟联系起来(By similarity)。 {ECO:0000250|UniProtKB:Q9Z2C8}。

组织特异性

Expressed in oocytes and testicular germ cells in the stage of spermatogonia to spermatocyte. Also observed placental trophoblasts, as well as in vascular smooth muscle cells in the pulmonary artery, myocardium, and skeletal muscle. Undetectable in epithelial cells in respiratory, gastrointestinal, and urogenital tracts. Up-regulated in various carcinomas and germ cell tumors (at protein level).

亚细胞定位

Cytoplasm