XPNPEP3 Q9NQH7

Xaa-Pro氨肽酶3 (X-Pro氨肽酶3) (EC 3.4.11.9) (氨肽酶P3) (APP3)

蛋白质信息 (UniProt)

Xaa-Pro氨肽酶3 (X-Pro氨肽酶3) (EC 3.4.11.9) (氨肽酶P3) (APP3)

Q9NQH7

功能描述

催化从肽的N末端去除倒数第二个脯氨酰残基，例如Leu-Pro-Ala (PubMed:25609706, PubMed:28476889)。对P1位置为Ala或Ser的肽也显示出低活性 (PubMed:28476889)。 {ECO:0000269|PubMed:25609706, ECO:0000269|PubMed:28476889}.; FUNCTION: [Isoform 1]: 促进TNFRSF1B介导的MAPK8/JNK1和MAPK9/JNK2磷酸化，提示其作为TNFRSF1B的接头蛋白发挥功能；该效应不依赖于XPNPEP3肽酶活性。可能抑制通过TNF-TNFRSF1B信号传导诱导的凋亡细胞死亡。 {ECO:0000269|PubMed:25609706}.

组织特异性

Isoform 1 and isoform 2 are widely expressed, with isoform 1 being more abundant.

亚细胞定位

[Isoform 1]: Mitochondrion

关键词

3D-structure Alternative splicing Aminopeptidase Cytoplasm Disease variant Hydrolase Manganese Metal-binding Metalloprotease Mitochondrion

外部链接

UniProt: Q9NQH7

NCBI Gene

GeneCards