WWC1 Q8IX03

KIBRA蛋白 (HBeAg结合蛋白3) (肾脏和脑蛋白) (KIBRA) (含WW域蛋白1)

功能描述

Hippo信号通路的调节因子，也称为Salvador-Warts-Hippo (SWH)通路 (PubMed:24682284)。增强LATS1和YAP1的磷酸化，并通过抑制Hippo通路的主要效应因子YAP1的转录活性，负向调节细胞增殖和器官生长 (PubMed:24682284)。与NF2协同诱导LATS1和LATS2的磷酸化，并在Hippo信号通路的调节中发挥作用 (PubMed:20159598)。作为ESR1的转录共激活因子，在DYNLL1介导的ESR1反式激活中起重要作用 (PubMed:16684779)。调节胶原刺激的ERK/MAPK级联反应的激活 (PubMed:18190796)。调节足细胞的定向迁移 (PubMed:18596123)。在认知和记忆表现中发挥作用 (PubMed:18672031)。在调节突触可塑性和学习基础的AMPA选择性谷氨酸受体 (AMPARs) 运输方面发挥重要作用 (By similarity)。 {ECO:0000250|UniProtKB:Q5SXA9, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:24682284}.

组织特异性

Expressed in mammary epithelial cells and breast cancer cell lines. Found in the luminal epithelium surrounding the ducts in the normal breast. In the brain, expressed in somatodendritic compartment of neurons in the cortex and hippocampus and in the cerebellum it is found in the Purkinje cells and some granule cells (at protein level). Detected in brain, heart, colon and kidney. In the kidney, expressed in glomerular podocytes, in some tubules and in the collecting duct.

亚细胞定位

Cytoplasm, perinuclear region