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WNT10B O00744

Wnt-10b蛋白 (Wnt-12蛋白)

蛋白质信息 (UniProt)

Wnt-10b蛋白 (Wnt-12蛋白)

O00744

功能描述

Wnt配体基因家族成员,编码分泌蛋白,激活Wnt信号级联反应。特异性激活经典Wnt/β-catenin信号通路,从而触发β-catenin/LEF/TCF介导的转录程序。参与控制干性、多能性和细胞命运决定的信号网络。在免疫系统、乳腺、脂肪组织、骨骼和皮肤中发挥作用。 {ECO:0000305|PubMed:16477437, ECO:0000305|PubMed:21447090, ECO:0000305|PubMed:27321946}。

组织特异性

Detected in most adult tissues. Highest levels were found in heart and skeletal muscle. Low levels are found in brain.

亚细胞定位

Secreted, extracellular space, extracellular matrix

关键词

Alternative splicing Developmental protein Disease variant Disulfide bond Extracellular matrix Glycoprotein Lipoprotein Phosphoprotein Proteomics identification Reference proteome