WFS1 O76024

沃尔弗拉明

功能描述

参与调节细胞Ca(2+)稳态，至少部分是通过调节内质网Ca(2+)库的填充状态来实现的 (PubMed:16989814)。负向调节内质网应激反应，并通过一种未知的非蛋白酶体依赖机制防止V-ATPase亚基ATP6V1A和ATP1B1降解，从而正向调节其稳定性 (PubMed:23035048)。 {ECO:0000269|PubMed:16989814, ECO:0000269|PubMed:23035048}。

组织特异性

Highly expressed in heart followed by brain, placenta, lung and pancreas. Weakly expressed in liver, kidney and skeletal muscle. Also expressed in islet and beta-cell insulinoma cell line.

亚细胞定位

Endoplasmic reticulum membrane