WDR73 Q6P4I2

整合因子复合体组装因子WDR73 (WD重复序列蛋白73)

功能描述

多蛋白复合物的组分，该复合物是整合体复合物RNA内切酶模块组装所必需的 (PubMed:39032489)。在细胞质中与INTS9和INTS11结合，稳定INTS9-INTS11异二聚体并阻断INTS11的活性位点 (PubMed:39032489)。随后BRAT1加入该复合物并堵塞INTS11的活性位点，导致WDR73释放以及INTS9和INTS11的核输入 (PubMed:39032489)。 {ECO:0000269|PubMed:39032489}。

组织特异性

Expressed in kidney and brain. In the kidney, expressed in glomeruli, most probably in podocytes, and in tubules (at protein level). In the brain, expressed in the cerebellum, with high levels in Purkinje cells and their projecting axons, in the deep cerebellar nuclei and in pyramidal neurons of the cerebral cortex (at protein level). In the white matter, mainly present in astrocytes, but not in oligodendrocytes (at protein level). Also highly expressed in endothelial cells of cerebral capillaries (at protein level).

亚细胞定位

Cytoplasm