WDR19 Q8NEZ3

WD重复序列包含蛋白19 (鞭毛内运输144同源物)

功能描述

作为IFT complex A (IFT-A)的组分，该复合物是G蛋白偶联受体(GPCRs)逆向纤毛运输及进入纤毛所必需的，参与纤毛功能和/或组装(PubMed:20889716)。对功能性IFT-A组装和GPCRs的纤毛进入至关重要(PubMed:20889716)。与BBSome复合物结合以介导纤毛运输(By similarity)。 {ECO:0000250|UniProtKB:Q3UGF1, ECO:0000269|PubMed:20889716}。

组织特异性

Some isoforms are tissue-specific. Highly expressed in the prostate. Lower expression in the cerebellum, pituitary gland, fetal lung, and pancreas. In normal prostate, expressed in both basal and luminal epithelial cells. No expression detected in fibromuscular stromal cells, endothelial cells, or infiltrating lymphocytes. Uniformed expression in prostate adenocarcinoma cells.

亚细胞定位

Cell projection, cilium