Wings apart-like蛋白同源物 (Friend of EBNA2蛋白) (WAPL黏连蛋白释放因子)
Wings apart-like蛋白同源物 (Friend of EBNA2蛋白) (WAPL黏连蛋白释放因子)
Q7Z5K2功能描述
有丝分裂中姐妹染色单体凝聚的调节因子，负向调节cohesin与染色质的结合 (PubMed:26299517)。参与间期姐妹染色单体凝聚及有丝分裂早期姐妹染色单体分离。将DNA复制与姐妹染色单体凝聚偶联。凝聚确保减数分裂和有丝分裂细胞中染色体分配的准确性，并在DNA修复中发挥重要作用。 {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203, ECO:0000269|PubMed:26299517}。
组织特异性
Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high level in skeletal muscle and heart.
亚细胞定位
[Isoform 2]: Nucleus.; SUBCELLULAR LOCATION: Nucleus. Chromosome
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