VTCN1 Q7Z7D3

含V-set结构域T细胞激活抑制因子1 (B7同源物4) (B7-H4) (B7h.5) (免疫共刺激蛋白B7-H4) (蛋白B7S1) (T细胞共刺激分子B7x)

功能描述

通过抑制T细胞活化、增殖、细胞因子产生和细胞毒性发育，负向调节T细胞介导的免疫应答。当表达于肿瘤巨噬细胞表面时，与调节性T细胞(Treg)共同在抑制肿瘤相关抗原特异性T细胞免疫中发挥重要作用。参与促进上皮细胞转化。 {ECO:0000250|UniProtKB:Q7TSP5, ECO:0000269|PubMed:15878339, ECO:0000269|PubMed:16606666, ECO:0000269|PubMed:17509674, ECO:0000269|PubMed:17875732}.

组织特异性

Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.

亚细胞定位

Cell membrane