血管活性肠多肽受体1 (VIP-R-1) (垂体腺苷酸环化酶激活多肽II型受体) (PACAP II型受体) (PACAP-R-2) (PACAP-R2) (VPAC1受体) (VPAC1R)
血管活性肠多肽受体1 (VIP-R-1) (垂体腺苷酸环化酶激活多肽II型受体) (PACAP II型受体) (PACAP-R-2) (PACAP-R2) (VPAC1受体) (VPAC1R)
P32241功能描述
G protein偶联受体，由神经肽血管活性肠肽(VIP)和垂体腺苷酸环化酶激活多肽(ADCYAP1/PACAP)激活(PubMed:35477937, PubMed:36385145, PubMed:8179610)。以VIP = PACAP27 > PACAP38的配体亲和力顺序结合VIP以及PACAP27和PACAP38生物活性肽(PubMed:35477937, PubMed:8179610)。配体结合引起构象变化，通过鸟苷酸结合蛋白(G proteins)触发信号传导并调节下游效应器的活性。激活cAMP依赖途径(PubMed:35477937, PubMed:36385145, PubMed:8179610)。 {ECO:0000269|PubMed:35477937, ECO:0000269|PubMed:36385145, ECO:0000269|PubMed:8179610}。
组织特异性
In lung, HT-29 colonic epithelial cells, Raji B-lymphoblasts. Lesser extent in brain, heart, kidney, liver and placenta. Not expressed in CD4+ or CD8+ T-cells. Expressed in the T-cell lines HARRIS, HuT 78, Jurkat and SUP-T1, but not in the T-cell lines Peer, MOLT-4, HSB and YT.
亚细胞定位
Cell membrane
关键词