VCAN P13611

多功能蛋白聚糖核心蛋白 (硫酸软骨素蛋白聚糖核心蛋白 2) (硫酸软骨素蛋白聚糖 2) (神经透明质酸结合蛋白) (GHAP) (大分子成纤维细胞蛋白聚糖) (PG-M)

功能描述

可能在细胞间信号传导以及连接细胞与细胞外基质中发挥作用。可能参与细胞运动、生长和分化的调节。结合透明质酸。

组织特异性

Detected in placenta (at protein level) (PubMed:32337544). Detected in cerebrospinal fluid, fibroblasts and urine (at protein level) (PubMed:25326458, PubMed:36213313). Expressed in the retina (at protein level) (PubMed:29777959). Cerebral white matter and plasma (PubMed:2469524). Isoform V0: Expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas (PubMed:8627343). Isoform V1: Expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas (PubMed:8627343). Isoform V2: Restricted to normal brain and gliomas (PubMed:8627343). Isoform V3: Found in all these tissues except medulloblastomas (PubMed:8627343).

亚细胞定位

Secreted, extracellular space, extracellular matrix