泛素羧基末端水解酶45 (EC 3.4.19.12) (去泛素化酶45) (泛素硫酯酶45) (泛素特异性加工蛋白酶45)
泛素羧基末端水解酶45 (EC 3.4.19.12) (去泛素化酶45) (泛素硫酯酶45) (泛素特异性加工蛋白酶45)
Q70EL2功能描述
催化SPDL1的去泛素化 (PubMed:30258100)。通过ERCC1的去泛素化在UV诱导的DNA损伤修复中发挥作用，促进其募集至DNA损伤位点 (PubMed:25538220)。可能参与光感受器功能的维持 (PubMed:30573563)。可能在正常视网膜发育中发挥作用 (By similarity)。在细胞迁移中发挥作用 (PubMed:30258100)。 {ECO:0000250|UniProtKB:E9QG68, ECO:0000269|PubMed:25538220, ECO:0000269|PubMed:30258100, ECO:0000269|PubMed:30573563}。
组织特异性
Widely expressed. High expression is detected in the cerebellum. In the eye, it is expressed at high levels in the optic nerve, sclera and retina, with relatively low levels in the choroid, lens and retinal pigment epithelium (PubMed:30573563).
亚细胞定位
Photoreceptor inner segment
关键词