UNC80 Q8N2C7

Unc-80同源蛋白

功能描述

NALCN钠通道复合物的辅助亚基，该复合物是一种电压门控离子通道，负责控制神经元兴奋性的静息Na(+)通透性 (By similarity)。被神经肽P物质、神经紧张素和细胞外Ca(2+)激活，通过控制NALCN依赖性钠漏电流的大小来调节神经元兴奋性。UNC80对于NALCN对细胞外Ca(2+)的敏感性至关重要 (By similarity)。 {ECO:0000250|UniProtKB:Q8BLN6}。

组织特异性

Moderately expressed in fetal brain, spinal cord, skeletal muscle, thymus, spleen, fetal liver, small intestine, colon, kidney and uterus. Highly expressed in adrenal gland, prostate and testis, as well as in brain and cerebellum.

亚细胞定位

Cell membrane