UNC5C O95185

Netrin受体UNC5C (Protein unc-5同源物3) (Protein unc-5同源物C)

功能描述

Netrin受体，为轴突导向所需 (By similarity)。介导发育中的神经系统在配体结合后神经生长锥的轴突排斥 (By similarity)。NTN1/Netrin-1结合可能导致UNC5C与微管中聚合的TUBB3解离，从而增加微管动力学并引起轴突排斥 (PubMed:28483977)。生长锥中的轴突排斥也可能由其与DCC的结合引起，这可能触发排斥信号 (By similarity)。可能还与DSCAM协作，参与不依赖DCC的NTN1介导的轴突排斥 (By similarity)。也参与不依赖DCC的皮质脊髓束轴突导向 (By similarity)。参与背根神经节轴突向脊髓的投射 (PubMed:28483977)。当未与netrin配体结合时，它还作为诱导凋亡所需的依赖受体发挥作用 (By similarity)。 {ECO:0000250|UniProtKB:O08747, ECO:0000250|UniProtKB:Q761X5, ECO:0000269|PubMed:28483977}。

组织特异性

Mainly expressed in brain (PubMed:9782087). Expressed in temporal lobe cortical neurons and in neurons of the hippocampal pyramidal layer (PubMed:25419706). Also expressed in kidney (PubMed:9782087). Not expressed in developing or adult lung (PubMed:9782087).

亚细胞定位

Cell membrane