蛋白unc-13同源物D (Munc13-4)
蛋白unc-13同源物D (Munc13-4)
Q70J99功能描述
在淋巴细胞的细胞毒性颗粒胞吐作用中发挥作用。为免疫突触处的颗粒成熟以及颗粒锚定和启动所必需。调节循环内体和晚期内体结构的组装，导致形成内体胞吐区室，该区室在免疫突触处与含穿孔蛋白的颗粒融合并许可其进行胞吐。调节肥大细胞中Ca(2+)依赖性分泌溶酶体胞吐作用。 {ECO:0000269|PubMed:15548590, ECO:0000269|PubMed:17237785}。
组织特异性
Expressed at high levels in spleen, thymus and leukocytes. Also expressed in lung and placenta, and at very low levels in brain, heart, skeletal muscle and kidney. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells.
亚细胞定位
Cytoplasm. Membrane; Peripheral membrane protein. Late endosome. Recycling endosome. Lysosome. Note=Colocalizes with cytotoxic granules at the plasma membrane. Localizes to endosomal exocytic vesicles.
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