UCN P55089

尿皮质素

功能描述

在体外刺激促肾上腺皮质激素(ACTH)的分泌(PubMed:8612563)。以高亲和力结合CRF受体1型、2-alpha和2-beta(PubMed:8612563)。在正常听阈的建立中发挥作用(By similarity)。减少食物摄入并调节胃体和血浆中的生长素释放肽水平(By similarity)。 {ECO:0000250|UniProtKB:P55090, ECO:0000250|UniProtKB:P81615, ECO:0000269|PubMed:8612563}。

组织特异性

Keratinocytes in epidermis and the outer and inner root sheaths of hair follicles, epithelium of sebaceous and sweat glands, erector pili muscle, cutaneous blood vessel walls, cutaneous nerves and dermal mononuclear cells (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481) (at protein level). Expressed in pituitary and adrenal glands (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481).

亚细胞定位

Secreted.