UBN1 Q9NPG3

核仁蛋白-1 (HIRA结合蛋白) (蛋白VT4) (广泛表达核蛋白)

功能描述

作为衰老的新型调节因子。参与衰老相关异染色质灶（SAHF）的形成，该结构抑制促增殖基因的表达。结合促增殖基因。可能为非复制依赖性染色质组装所必需。{ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:19029251}。

组织特异性

Ubiquitous. Also expressed in numerous tumors and cancer cell lines.

亚细胞定位

Nucleus, nucleoplasm. Nucleus, PML body. Cell junction, tight junction. Note=Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis.