泛素结合因子E4 B (EC 2.3.2.27) (神经母细胞瘤纯合缺失基因1) (RING型E3泛素转移酶E4 B) (泛素融合降解蛋白2)
泛素结合因子E4 B (EC 2.3.2.27) (神经母细胞瘤纯合缺失基因1) (RING型E3泛素转移酶E4 B) (泛素融合降解蛋白2)
O95155功能描述
泛素-protein连接酶，可能作为E3连接酶与特定的E1和E2连接酶协同发挥作用 (By similarity)。也可能作为E4连接酶发挥作用，介导在由另一种E3泛素连接酶泛素化的底物上组装多泛素链 (By similarity)。可能通过与STUB1和VCP/p97协同作用，通过靶向肌球蛋白伴侣UNC45B进行蛋白酶体降解来调节横纹肌中的肌球蛋白组装 (PubMed:17369820)。 {ECO:0000250|UniProtKB:P54860, ECO:0000250|UniProtKB:Q9ES00, ECO:0000269|PubMed:17369820}。
组织特异性
Expressed in differentiated myotubes (at protein level) (PubMed:17369820). Highest expression in ovary, testis, heart and skeletal muscle (PubMed:11802788). Expression is low in colon, thymus and peripheral blood leukocytes (PubMed:11802788). Almost undetectable in lung and spleen (PubMed:11802788).
亚细胞定位
Cytoplasm
关键词