UBE2D2 P62837

泛素结合酶E2 D2 (EC 2.3.2.23) ((E3非依赖性) E2泛素结合酶D2) (EC 2.3.2.24) (E2泛素结合酶D2) (泛素载体蛋白D2) (泛素结合酶E2(17)KB 2) (泛素结合酶E2-17 kDa 2) (泛素蛋白连接酶D2) (p53调节泛素结合酶1)

功能描述

接受来自E1复合物的泛素并催化其与其他蛋白质的共价连接 (PubMed:10329681, PubMed:18042044, PubMed:18703417, PubMed:20061386, PubMed:20403326, PubMed:20525694, PubMed:26475854, PubMed:28322253)。催化'Lys-48'连接的多泛素化 (PubMed:10329681, PubMed:18042044, PubMed:18359941, PubMed:18703417, PubMed:20061386, PubMed:20403326, PubMed:20525694, PubMed:26475854)。介导短寿命和异常蛋白质的选择性降解 (PubMed:10329681, PubMed:18042044, PubMed:18359941, PubMed:18703417, PubMed:20061386, PubMed:20403326, PubMed:20525694, PubMed:26475854)。在E6/E6-AP诱导的p53/TP53泛素化中发挥作用 (PubMed:15280377)。介导PEX5和SQSTM1的泛素化以及STUB1和TRAF6的自身泛素化 (PubMed:18359941, PubMed:28322253)。参与信号诱导的NFKBIA结合及随后的降解、FBXW2介导的GCM1泛素化和降解、MDM2依赖性的p53/TP53降解，以及病毒感染响应中RIGI对线粒体中MAVS的激活 (PubMed:18703417, PubMed:20403326)。对IRF3的病毒激活至关重要 (PubMed:19854139)。 {ECO:0000269|PubMed:10329681, ECO:0000269|PubMed:15280377, ECO:0000269|PubMed:18042044, ECO:0000269|PubMed:18359941, ECO:0000269|PubMed:18703417, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20403326, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:26475854, ECO:0000269|PubMed:28322253}。