TWIST2 Q8WVJ9

Twist相关蛋白2 (A类碱性螺旋-环-螺旋蛋白39) (bHLHa39) (真皮表达蛋白1) (Dermo-1)

功能描述

作为异源二聚体结合E-box共有序列5'-CANNTG-3'，并抑制MYOD1、MYOG、MEF2A和MEF2C的转录激活。也抑制促炎细胞因子（如TNFA和IL1B）的表达。参与出生后糖原储存和能量代谢（通过相似性）。在骨发生过程中抑制前成骨细胞的过早或异位分化，可能是通过改变成骨细胞对外部生长因子的内部信号转导反应来实现的。 {ECO:0000250, ECO:0000269|PubMed:11062344}。

组织特异性

In the embryo, highly expressed in chondrogenic cells. In embryonic skin, expressed in the undifferentiated mesenchymal layer beneath the epidermis which later develops into the dermis. Expressed in early myeloid cells but not in lymphoid cells in the liver. Expression also detected in the secretory ependymal epithelium of the choroid plexus primordium. In the adult, expressed in secreting glandular tissues and tubules.

亚细胞定位

Nucleus