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TTYH2 Q9BSA4

Tweety同源蛋白2 (hTTY2) (体积调节阴离子通道亚基TTYH2)

蛋白质信息 (UniProt)

Tweety同源蛋白2 (hTTY2) (体积调节阴离子通道亚基TTYH2)

Q9BSA4

功能描述

钙非依赖性、肿胀依赖性的体积调节阴离子通道 (VRAC-swell),通过氯离子等阴离子和谷氨酸等有机渗透溶质的流出,在脑部的调节性体积减小 (RVD) 过程中发挥关键作用 (By similarity)。可能是大电导Ca(2+)激活的氯离子通道 (PubMed:15010458)。 {ECO:0000250|UniProtKB:Q3TH73, ECO:0000269|PubMed:15010458}。

组织特异性

Expressed at higher level in brain and testis and at lower levels in heart, ovary, spleen and peripheral blood leukocytes. Up-regulated in 13 of 16 renal cell carcinoma samples examined. Up-regulated in colon carcinoma.

亚细胞定位

Cell membrane

关键词

3D-structure Alternative splicing Calcium Cell membrane Chloride Chloride channel Disulfide bond Glycoprotein Ion channel Ion transport