TSTD1 Q8NFU3

硫代硫酸:谷胱甘肽硫转移酶 (TST) (EC 2.8.1.3)

功能描述

硫代硫酸:谷胱甘肽硫转移酶 (TST)，用于产生S-硫烷基谷胱甘肽 (GSS(-))，这是硫化氢代谢的中间产物 (PubMed:24981631)。提供了哺乳动物H(2)S代谢第一步与后续步骤之间的联系，第一步由硫化物:醌氧化还原酶 (SQOR) 执行，催化H(2)S转化为硫代硫酸，随后硫加氧酶 (SDO) 利用GSS(-)作为底物 (PubMed:24981631)。不可逆的SDO反应与可逆的TST反应的热力学偶联提供了一个模型，解释了以硫代硫酸作为硫烷供体的生理相关反应 (PubMed:24981631)。GSS(-)自发与谷胱甘肽反应生成谷胱甘肽二硫化物 (Probable)。 {ECO:0000269|PubMed:24981631, ECO:0000305}。

组织特异性

Highly expressed in kidney, liver and skeletal muscle. Lower levels of expression in heart, colon, thymus, spleen, placenta and lung. Weakly expressed in brain, small intestine and peripheral blood leukocytes. Expressed at high levels in the breast carcinoma cell lines MCF-7 and MDA-MB-468 and at a lower level in the breast carcinoma cell line MDA-MB-231, the colon carcinoma call line LoVo and the lung carcinoma cell line A-549. No expression in the cell lines EFO-27 and HeLa, or the normal breast tissue cell lines MCF-10A and H184A1. Detected in invasive ductal carcinoma, but not in the adjacent tissues.

亚细胞定位

Cytoplasm, perinuclear region