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TSPO P30536

转位蛋白 (线粒体苯二氮卓受体) (PKBS) (外周型苯二氮卓受体) (PBR)

蛋白质信息 (UniProt)

转位蛋白 (线粒体苯二氮卓受体) (PKBS) (外周型苯二氮卓受体) (PBR)

P30536

功能描述

能结合原卟啉IX,可能在卟啉和血红素的转运中发挥作用 (By similarity)。促进胆固醇跨线粒体膜转运,可能在脂质代谢中发挥作用 (PubMed:24814875),但其确切的生理作用尚有争议。显然不是类固醇激素生物合成所必需的。最初被鉴定为外周型苯二氮卓受体;也能结合异喹啉甲酰胺类 (PubMed:1847678)。 {ECO:0000250, ECO:0000269|PubMed:1847678, ECO:0000269|PubMed:24814875}。

组织特异性

Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids.

亚细胞定位

Mitochondrion membrane

关键词

Alternative splicing Lipid transport Membrane Mitochondrion Proteomics identification Receptor Reference proteome Transmembrane Transmembrane helix Transport