TSC22D3 Q99576

TSC22结构域家族蛋白3 (DSIP免疫反应肽) (蛋白DIP) (hDIP) (Delta睡眠诱导肽免疫反应物) (糖皮质激素诱导的亮氨酸拉链蛋白) (GILZ) (TSC-22样蛋白) (TSC-22相关蛋白) (TSC-22R)

功能描述

通过抑制FOXO3A转录活性，保护T细胞免受IL2剥夺诱导的细胞凋亡，从而导致促凋亡因子BCL2L11的下调 (PubMed:15031210)。在巨噬细胞中，在糖皮质激素和IL10的抗炎及免疫抑制作用中发挥作用 (PubMed:12393603)。在T细胞中，抑制抗CD3诱导的NFKB1核易位，从而抑制NFKB1 DNA结合活性 (PubMed:11468175)。在体外，抑制AP-1转录因子复合物DNA结合活性 (By similarity)。 {ECO:0000250|UniProtKB:Q9Z2S7, ECO:0000269|PubMed:11468175, ECO:0000269|PubMed:12393603, ECO:0000269|PubMed:15031210}.; FUNCTION: [Isoform 1]: 通过结合并调节MYOD1和HDAC1转录活性导致MYOG表达降低，从而抑制肌源性分化并介导糖皮质激素的抗肌源性作用。 {ECO:0000250|UniProtKB:Q9Z2S7}.

组织特异性

Ubiquitously expressed, including in the fetal brain and liver (PubMed:26752201). Expressed in brain, lung, spleen and skeletal muscle (PubMed:11313722, PubMed:12393603). Lower levels detected in heart and kidney (PubMed:11313722, PubMed:12393603). Not detected in the pancreas (PubMed:11313722). In non-lymphoid tissues, in the absence of inflammation, the major source of constitutive expression is the macrophage lineage (PubMed:12393603). Also expressed in cells from different hemopoietic cell lineages, including bone marrow cells, CD34+ stem cells, mature B- and T-cells, monocytes and granulocytes (PubMed:11313722). Down-regulated in activated macrophages from inflammatory lesions of delayed-type hypersensitivity (DTH) reactions, such as in tuberculosis and in Crohn disease, whereas in Burkitt lymphoma, persists in macrophages involved in the phagocytosis of apoptotic malignant cells (PubMed:12393603).

亚细胞定位

[Isoform 1]: Cytoplasm