TRPV5 Q9NQA5

瞬时受体电位阳离子通道亚家族V成员5 (TrpV5) (钙转运蛋白2) (CaT2) (上皮钙通道1) (ECaC) (ECaC1) (Osm-9样TRP通道3) (OTRPC3)

功能描述

组成型活性的钙选择性阳离子通道，被认为参与肾脏和肠道中Ca(2+)的重吸收 (PubMed:11549322, PubMed:18768590)。为肾脏远曲小管中Ca(2+)的正常重吸收所必需 (By similarity)。该通道被低胞内钙水平激活，电流呈现内向整流特性 (PubMed:11549322, PubMed:18768590)。Ca(2+)依赖性反馈调节包括快速通道失活和缓慢电流衰减 (By similarity)。与TRPV6的异源组装似乎会改变通道特性。TRPV5-TRPV6异源多聚体串联体表现出电压依赖性门控 (By similarity)。 {ECO:0000250|UniProtKB:P69744, ECO:0000250|UniProtKB:Q9XSM3, ECO:0000269|PubMed:11549322, ECO:0000269|PubMed:18768590}。

组织特异性

Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum.

亚细胞定位

Apical cell membrane