TRPV3 Q8NET8

瞬时受体电位阳离子通道亚家族V成员3 (TrpV3) (香草素受体样3) (VRL-3)

功能描述

非选择性钙通透阳离子通道 (PubMed:12077604, PubMed:12077606, PubMed:26818531, PubMed:37648856, PubMed:38691614)。它被无害（温热）温度激活，并在超过39摄氏度的伤害性温度下显示增强的反应 (PubMed:12077604, PubMed:12077606)。激活表现出外向整流 (PubMed:12077604)。通道孔可以扩张以提供对较大阳离子的通透性 (PubMed:37648856)。可能与TRPV1结合并调节其活性 (PubMed:12077606)。是毛发生长和周期的负调节因子：TRPV3偶联信号传导抑制毛囊中角质形成细胞的增殖，并诱导细胞凋亡和毛囊过早退化（退行期） (PubMed:21593771)。 {ECO:0000269|PubMed:12077604, ECO:0000269|PubMed:12077606, ECO:0000269|PubMed:21593771, ECO:0000269|PubMed:26818531, ECO:0000269|PubMed:37648856, ECO:0000269|PubMed:38691614}。

组织特异性

Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion (at protein level). Expressed in the keratinocyte layers of the outer root sheath and, to lesser extent, to the matrix of the hair follicles (at protein level).

亚细胞定位

Cell membrane