TRPM3 Q9HCF6

瞬时受体电位阳离子通道亚家族M成员3 (长瞬时受体电位通道3) (LTrpC-3) (LTrpC3) (Melastatin-2) (MLSN2)

功能描述

组成型活性、非选择性二价阳离子传导通道，对Ca(2+)、Mn(2+)和Mg(2+)具有通透性，其中对Ca(2+)的通透性最高。然而，其活性可通过升高温度以及配体（包括内源性神经类固醇硫酸孕烯醇酮和鞘氨醇-1）增强，并被细胞内Mg(2+)抑制 (PubMed:12672799, PubMed:12672827, PubMed:32343227)。参与多种细胞过程，包括胰岛素/肽分泌、血管收缩与舒张、有害热感知、炎症和自发痛敏感性。在背根神经节神经元中，作为热敏通道发挥作用，用于检测有害热和自发痛。推测在β细胞中作为离子型类固醇受体起作用，实际上硫酸孕烯醇酮会导致Ca(2+)内流并增强胰岛素分泌。介导Zn(2+)摄取进入胰腺β细胞分泌颗粒腔内，从而调节胰岛素分泌 (By similarity)。与TRPM1形成异源多聚体离子通道，对Ca(2+)和Zn(2+)离子具有通透性 (PubMed:21278253)。存在多种剪接变体，其生物物理特性存在显著差异 (By similarity)。 {ECO:0000250|UniProtKB:J9SQF3, ECO:0000269|PubMed:12672799, ECO:0000269|PubMed:12672827, ECO:0000269|PubMed:21278253, ECO:0000269|PubMed:32343227}。

组织特异性

Expressed primarily in the kidney and, at lower levels, in brain, testis, ovary, pancreas and spinal cord. Expression in the brain and kidney was determined at protein level. In the kidney, expressed predominantly in the collecting tubular epithelium in the medulla, medullary rays, and periglomerular regions; in the brain, highest levels are found in the cerebellum, choroid plexus, the locus coeruleus, the posterior thalamus and the substantia nigra. Down-regulated in renal tumors compared to normal kidney. Expressed in the lens (PubMed:25090642).

亚细胞定位

Cell membrane