TRPM1 Q7Z4N2

瞬时受体电位阳离子通道亚家族M成员1 (长瞬时受体电位通道1) (LTrpC1) (Melastatin-1)

功能描述

组成性开放的非选择性二价阳离子传导通道，介导Ca(2+)、Mg(2+)、Mn(2+)、Ba(2+)和Ni(2+)流入细胞质，导致膜去极化 (PubMed:11535825, PubMed:19436059, PubMed:21278253)。对锌离子不通透 (PubMed:21278253)。此外，与TRPM3形成异聚离子通道，对钙离子和锌离子通透 (PubMed:21278253)。在视网膜ON双极细胞去极化光反应中起重要作用 (PubMed:19878917, PubMed:19896109)。在黑暗中，谷氨酸的持续释放激活谷氨酸G蛋白偶联受体GRM6，其激活诱导G(o)蛋白和beta-gamma G蛋白二聚体的释放。两个亚基均可相互作用并使TRPM1通道失活。光照开始诱导谷氨酸释放减少和GRM6失活，导致通道开放和膜去极化 (By similarity)。可能在转移抑制中发挥作用 (PubMed:9537257)。 {ECO:0000250|UniProtKB:Q2TV84, ECO:0000269|PubMed:11535825, ECO:0000269|PubMed:19436059, ECO:0000269|PubMed:19878917, ECO:0000269|PubMed:19896109, ECO:0000269|PubMed:21278253, ECO:0000269|PubMed:9537257}。

组织特异性

Expressed in the retina where it localizes to the outer plexiform layer. Specifically, it is expressed in retinal bipolar cells (BPCs) of the ON subtype (PubMed:30027108). Highly expressed in benign melanocytic nevi and diffusely expressed in various in situ melanomas, but not detected in melanoma metastases. Also expressed in melanocytes and pigmented metastatic melanoma cell lines. In melanocytes expression appears to be regulated at the level of transcription and mRNA processing.

亚细胞定位

Cell membrane