TRIP10 Q15642

Cdc42相互作用蛋白4 (Protein Felic) (耐盐蛋白) (hSTP) (甲状腺受体相互作用蛋白10) (TR相互作用蛋白10) (TRIP-10)

功能描述

响应胰岛素信号将GLUT4易位至质膜所必需 (By similarity)。在内吞过程中协调膜小管化与肌动蛋白细胞骨架重组所必需。结合脂质，如磷脂酰肌醇4,5-二磷酸和磷脂酰丝氨酸，并促进膜内陷和小管形成。还通过招募WASL/N-WASP促进CDC42诱导的肌动蛋白聚合，进而激活Arp2/3复合物。肌动蛋白聚合可能促进膜小管断裂以形成内吞囊泡。伪足体（单核细胞来源细胞特有的富含肌动蛋白的粘附结构）的形成所必需。可能为FASLG/FASL的溶酶体滞留所必需。 {ECO:0000250, ECO:0000269|PubMed:11069762, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391}。

组织特异性

Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea.

亚细胞定位

Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection, phagocytic cup. Note=Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity). Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9.