TRIM40 Q6P9F5

E3泛素连接酶TRIM40 (EC 2.3.2.27) (推测E3 NEDD8-蛋白连接酶) (环指蛋白35)

蛋白质信息 (UniProt)

E3泛素连接酶TRIM40 (EC 2.3.2.27) (推测E3 NEDD8-蛋白连接酶) (环指蛋白35)

Q6P9F5

功能描述

E3泛素-protein连接酶，在限制先天免疫应答中发挥作用 (PubMed:21474709, PubMed:29117565)。通过泛素化RIGI和IFIH1受体介导RLR信号通路的抑制，导致其蛋白酶体降解 (PubMed:21474709)。还促进IKBKG/NEMO的类泛素化，稳定NFKBIA，从而抑制NF-kappa-B核易位和激活 (PubMed:21474709)。 {ECO:0000269|PubMed:21474709, ECO:0000269|PubMed:29117565}。

组织特异性

Highly expressed in normal gastrointestinal epithelia but that is down-regulated in gastrointestinal carcinomas and chronic inflammatory lesions of the gastrointestinal tract.

关键词

Alternative splicing Coiled coil Metal-binding Proteomics identification Reference proteome Transferase Ubl conjugation pathway Zinc Zinc-finger

外部链接

UniProt: Q6P9F5

NCBI Gene

GeneCards