TRIM36 Q9NQ86

E3泛素蛋白连接酶TRIM36 (EC 2.3.2.27) (环指蛋白98) (RING型E3泛素转移酶TRIM36) (含三方基序蛋白36) (锌结合蛋白Rbcc728)

蛋白质信息 (UniProt)

E3泛素蛋白连接酶TRIM36 (EC 2.3.2.27) (环指蛋白98) (RING型E3泛素转移酶TRIM36) (含三方基序蛋白36) (锌结合蛋白Rbcc728)

Q9NQ86

功能描述

E3泛素-蛋白连接酶，介导靶蛋白的泛素化及其随后的蛋白酶体降解。参与染色体分离和细胞周期调控 (PubMed:28087737)。可能在顶体反应和受精中发挥作用。 {ECO:0000250|UniProtKB:Q80WG7, ECO:0000269|PubMed:28087737}。

组织特异性

Highly expressed in testis, prostate and brain (PubMed:15145053). Weakly expressed in kidney, lung and heart (PubMed:15145053). Expressed in fetal tissues (PubMed:28087737).

亚细胞定位

Cytoplasm

关键词

3D-structure Alternative splicing Coiled coil Cytoplasm Cytoplasmic vesicle Cytoskeleton Disease variant Metal-binding Proteomics identification Reference proteome

外部链接

UniProt: Q9NQ86

NCBI Gene

GeneCards