TP73 O15350

肿瘤蛋白p73 (p53样转录因子) (p53相关蛋白)

蛋白质信息 (UniProt)

肿瘤蛋白p73 (p53样转录因子) (p53相关蛋白)

O15350

功能描述

参与DNA损伤的凋亡反应。含有反式激活结构域的isoforms具有促凋亡作用，缺乏该结构域的isoforms具有抗凋亡作用并阻断p53和具有反式激活功能的p73 isoforms的功能。可能是一种肿瘤抑制蛋白。是FOXJ1表达的激活剂 (By similarity)。它是肺纤毛细胞分化正调控的必需因子 (PubMed:34077761)。 {ECO:0000250|UniProtKB:Q9JJP2, ECO:0000269|PubMed:10203277, ECO:0000269|PubMed:11753569, ECO:0000269|PubMed:18174154, ECO:0000269|PubMed:34077761}。

组织特异性

Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue. Expressed in the respiratory epithelium (PubMed:34077761).

亚细胞定位

Nucleus

关键词

3D-structure Activator Alternative promoter usage Alternative splicing Apoptosis Cell cycle Ciliopathy Cytoplasm Disease variant DNA-binding

外部链接

UniProt: O15350

NCBI Gene

GeneCards