TOP2B Q02880

DNA拓扑异构酶2-β (EC 5.6.2.2) (DNA拓扑异构酶II, β同工酶)

蛋白质信息 (UniProt)

DNA拓扑异构酶2-β (EC 5.6.2.2) (DNA拓扑异构酶II, β同工酶)

Q02880

功能描述

关键解连环酶，通过结合两个双链DNA分子，在其中一条链上产生双链断裂，使完整的链穿过断裂的链，并重新连接断裂的链，从而改变DNA拓扑结构。在B细胞分化中起作用。 {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}。

组织特异性

Expressed in the tonsil, spleen, lymph node, thymus, skin, pancreas, testis, colon, kidney, liver, brain and lung (PubMed:9155056). Also found in breast, colon and lung carcinomas, Hodgkin's disease, large-cell non-Hodgkin's lymphoma, lymphocytic lymphomas and seminomas (PubMed:9155056).

亚细胞定位

Nucleus, nucleolus

关键词

3D-structure Acetylation Alternative splicing ATP-binding Autism spectrum disorder Disease variant DNA-binding Isomerase Isopeptide bond Magnesium

外部链接

UniProt: Q02880

NCBI Gene

GeneCards