TNN Q9UQP3

Tenascin-N (TN-N) (Tenascin-W) (TN-W)

功能描述

细胞外基质蛋白，似乎是ITGA8:ITGB1、ITGAV:ITGB1和ITGA4:ITGB1的配体 (By similarity) (PubMed:17909022)。参与海马外植体中的神经突生长和细胞迁移 (By similarity)。在软骨内骨形成过程中，抑制由经典WNT信号传导介导的成骨细胞增殖和分化 (By similarity)。在肿瘤中，通过内皮细胞的延伸、迁移和出芽刺激血管生成 (PubMed:19884327)。在大多数乳腺肿瘤中表达，可能通过支持乳腺癌细胞的迁移行为促进肿瘤发生 (PubMed:17909022)。 {ECO:0000250|UniProtKB:Q80YX1, ECO:0000250|UniProtKB:Q80Z71, ECO:0000269|PubMed:17909022, ECO:0000269|PubMed:19884327}。

组织特异性

Not detected in normal adult mammary tissues or brain but expressed in most breast tumors and brain tumors, such as glioblastomas, astrocytomas and oligodendrogliomas, tested (PubMed:17909022, PubMed:19884327). In brain tumors, detected around the endothelial cell layer of the clood vessels (PubMed:19884327).

亚细胞定位

Secreted, extracellular space, extracellular matrix