聚[ADP-核糖]聚合酶端锚酶-2 (EC 2.4.2.30) (ADP-核糖转移酶白喉毒素样6) (ARTD6) (聚[ADP-核糖]聚合酶5B) (蛋白质聚ADP-核糖转移酶端锚酶-2) (EC 2.4.2.-) (TNKS-2) (TRF1相互作用锚蛋白相关ADP-核糖聚合酶2) (端锚酶II) (端锚酶-2) (TANK2) (端锚酶样蛋白) (端锚酶相关蛋白)
聚[ADP-核糖]聚合酶端锚酶-2 (EC 2.4.2.30) (ADP-核糖转移酶白喉毒素样6) (ARTD6) (聚[ADP-核糖]聚合酶5B) (蛋白质聚ADP-核糖转移酶端锚酶-2) (EC 2.4.2.-) (TNKS-2) (TRF1相互作用锚蛋白相关ADP-核糖聚合酶2) (端锚酶II) (端锚酶-2) (TANK2) (端锚酶样蛋白) (端锚酶相关蛋白)
Q9H2K2功能描述
参与Wnt信号通路、端粒长度和囊泡运输等多种过程的聚ADP核糖转移酶 (PubMed:11739745, PubMed:11802774, PubMed:19759537, PubMed:21478859, PubMed:23622245, PubMed:25043379)。作为Wnt信号通路的激活剂，通过介导AXIN1和AXIN2（beta-catenin破坏复合物的2个关键组分）的聚ADP核糖基化发挥作用：聚ADP核糖基化的靶蛋白被RNF146识别，RNF146介导它们的泛素化及随后的降解 (PubMed:19759537, PubMed:21478859)。也介导BLZF1和CASC3的聚ADP核糖基化，随后募集RNF146并发生泛素化 (PubMed:21478859)。介导TERF1的聚ADP核糖基化，从而有助于端粒长度的调节 (PubMed:11739745)。刺激26S蛋白酶体活性 (PubMed:23622245)。 {ECO:0000269|PubMed:11739745, ECO:0000269|PubMed:11802774, ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:21478859, ECO:0000269|PubMed:23622245, ECO:0000269|PubMed:25043379}。
组织特异性
Highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Highly expressed in fetal liver, heart and brain.
亚细胞定位
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Nucleus. Chromosome, telomere
关键词