TNIP3 Q96KP6

TNFAIP3相互作用蛋白3 (A20结合的NF-κB活化抑制剂3) (ABIN-3) (李斯特菌诱导基因蛋白)

功能描述

结合锌指蛋白TNFAIP3，并抑制由肿瘤坏死因子、Toll样受体4 (TLR4)、白细胞介素-1和12-O-十四烷酰佛波醇-13-乙酸酯诱导的NF-kappa-B活化。过表达在TRAF6下游和IKBKB上游水平抑制响应脂多糖的NF-kappa-B依赖性基因表达。NF-kappa-B抑制不依赖于TNFAIP3结合。 {ECO:0000269|PubMed:17088249}。

组织特异性

Highly expressed in lung, lymph node, thymus and fetal liver. Expressed at lower levels in bone marrow, brain, kidney, spleen, leukocytes and tonsils. Could be detected in heart, salivary gland, adrenal gland, pancreas, ovary and fetal brain. High levels detected in liver, colon, small intestine, muscle, stomach, testis, placenta, thyroid, uterus, prostate, skin and PBL.