肿瘤坏死因子受体超家族成员10B (死亡受体5) (TNF相关凋亡诱导配体受体2) (TRAIL受体2) (TRAIL-R2) (CD抗原CD262)
肿瘤坏死因子受体超家族成员10B (死亡受体5) (TNF相关凋亡诱导配体受体2) (TRAIL受体2) (TRAIL-R2) (CD抗原CD262)
O14763功能描述
细胞毒性配体TNFSF10/TRAIL的受体 (PubMed:10549288)。适配分子FADD将caspase-8募集到激活的受体。由此产生的死亡诱导信号复合物 (DISC) 执行caspase-8蛋白水解激活，从而启动随后的介导细胞凋亡的caspase（天冬氨酸特异性半胱氨酸蛋白酶）级联反应。促进NF-kappa-B的激活。对于内质网应激诱导的细胞凋亡至关重要。 {ECO:0000269|PubMed:10542098, ECO:0000269|PubMed:10549288, ECO:0000269|PubMed:15322075}。
组织特异性
Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.
亚细胞定位
Membrane; Single-pass type I membrane protein.
关键词