肿瘤坏死因子α诱导蛋白8 (TNF alpha-induced protein 8) (头颈肿瘤和转移相关蛋白) (MDC-3.13) (NF-κB诱导含DED蛋白) (NDED) (SCC-S2) (TNF诱导蛋白GG2-1)
肿瘤坏死因子α诱导蛋白8 (TNF alpha-induced protein 8) (头颈肿瘤和转移相关蛋白) (MDC-3.13) (NF-κB诱导含DED蛋白) (NDED) (SCC-S2) (TNF诱导蛋白GG2-1)
O95379功能描述
作为细胞凋亡的负调控因子，可能在肿瘤进展中发挥作用。通过抑制caspase-8活性但不抑制procaspase-8的加工，从而抑制TNF介导的细胞凋亡，随后导致BID裂解和caspase-3激活受抑制。 {ECO:0000269|PubMed:10644768, ECO:0000269|PubMed:11346652, ECO:0000269|PubMed:14724590}。
组织特异性
Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle.
亚细胞定位
Cytoplasm
关键词