TMEM9 Q9P0T7

质子转运V型ATP酶复合物组装调节因子TMEM9 (v-ATPase组装调节因子TMEM9) (真皮乳头衍生蛋白4) (跨膜蛋白9) (蛋白TMEM9)

功能描述

跨膜蛋白，结合并促进溶酶体质子转运V型ATPase (v-ATPase)的组装，从而增强溶酶体酸化和运输 (PubMed:30374053)。通过将v-ATPase辅助蛋白ATP6AP2和v-ATPase亚基ATP6V0D1聚集在一起，允许v-ATPase复合物的形成和激活 (PubMed:30374053)。TMEM9控制的囊泡酸化通过溶酶体降解腺瘤性结肠息肉病蛋白/APC，诱导参与发育、组织稳态和组织再生的Wnt/beta-catenin信号通路的过度激活 (PubMed:30374053, PubMed:32380568)。在肝脏中，参与肝脏再生 (PubMed:32380568)。 {ECO:0000269|PubMed:30374053, ECO:0000269|PubMed:32380568}。

组织特异性

Highly expressed in adrenal gland, thyroid gland, testis, ovary and prostate (PubMed:12359240). Moderate expression in trachea, spinal cord, stomach, colon, small intestine and spleen (PubMed:12359240, PubMed:30374053). Low expression in bone marrow, lymph node, thymus and peripheral blood lymphocytes (PubMed:12359240). Expression is detected in hematopoietic cell lines including those of myeloid, erythroid, B- and T-cell origin (PubMed:12359240).

亚细胞定位

Lysosome membrane