TMEM33 P57088

跨膜蛋白33 (Protein DB83) (SHINC-3)

功能描述

通过调节细胞内钙稳态，作为管状内质网（ER）网络的调节因子。在机制上，刺激PKD2钙依赖性活性（通过相似性）。抑制RTN3/4诱导的ER小管形成（PubMed:25612671）。正向调节PERK介导和IRE1介导的未折叠蛋白反应信号传导（PubMed:26268696）。在血管生成过程中，对VEGF介导的ER钙库释放Ca(2+)起重要作用（PubMed:30760708）。还通过与RNF26相互作用，调节cGAS-STING通路的先天免疫信号传导（PubMed:32614325）。作为丙酮酸激酶/PKM的下游效应因子参与脂质代谢。与RNF5形成复合物，促进SCAP在ER膜上的多聚泛素化及随后的降解（PubMed:34487377）。 {ECO:0000250|UniProtKB:Q9CR67, ECO:0000269|PubMed:25612671, ECO:0000269|PubMed:26268696, ECO:0000269|PubMed:30760708, ECO:0000269|PubMed:32614325, ECO:0000269|PubMed:34487377}。

组织特异性

Prostate cancer and several cancer cell lines (at protein level). Widely expressed. Expressed at higher levels in endocrine-resistant breast cancer cells as compared to endocrine-sensitive breast cancer cells. Expressed at higher levels in early recurrence breast cancer tissues as compared to non-recurrent breast tumors.

亚细胞定位

Endoplasmic reticulum membrane