Toll样受体3 (CD抗原CD283)
Toll样受体3 (CD抗原CD283)
O15455功能描述
先天免疫和适应性免疫的关键组分。TLRs (Toll样受体) 通过识别微生物特有的分子模式，控制宿主针对病原体的免疫反应。TLR3 是一种核酸感应型 TLR，可被双链 RNA（病毒感染的标志）激活。通过接头蛋白 TRIF/TICAM1 发挥作用，导致 NF-kappa-B 激活、IRF3 核易位、细胞因子分泌和炎症反应。 {ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:12539043, ECO:0000269|PubMed:16043704, ECO:0000269|PubMed:16144834, ECO:0000269|PubMed:16720699, ECO:0000269|PubMed:16858407, ECO:0000269|PubMed:17178723, ECO:0000269|PubMed:18172197, ECO:0000269|PubMed:22611194}。
组织特异性
Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons.
亚细胞定位
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane. Early endosome
关键词