TLN1 Q9Y490

塔林蛋白-1

功能描述

高分子量细胞骨架蛋白，富集于细胞-基质和细胞-细胞接触区域。参与主要细胞骨架结构与质膜的连接。与KANK1共同组织皮层微管稳定复合体（CMSCs）的组装，该复合体定位于控制粘着斑（FAs）边缘的微管-肌动蛋白交互作用。 {ECO:0000250|UniProtKB:P26039}。

组织特异性

[Isoform 2]: Expressed at low to non-detectable levels in many tissues but highly expressed in skin and pancreas with other tissues including kidney cortex, endocervix, testis, pituitary, liver, and spleen also showing robust expression.

亚细胞定位

Cell projection, ruffle membrane