丝氨酸/苏氨酸蛋白激酶 tousled 样 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled 样激酶 2)
丝氨酸/苏氨酸蛋白激酶 tousled 样 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled 样激酶 2)
Q86UE8功能描述
参与 chromatin 组装过程的 Serine/threonine-protein kinase，可能也参与 DNA 复制、转录、修复和染色体分离 (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565)。磷酸化 chromatin 组装因子 ASF1A 和 ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069)。ASF1A 的磷酸化阻止其 proteasome 介导的降解，从而增强 chromatin 组装 (PubMed:20016786)。氨基酸饥饿诱导自噬的负调控因子 (PubMed:22354037)。 {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:35136069, ECO:0000269|PubMed:9427565}。
组织特异性
Detected in placenta, fetal liver, kidney, pancreas, heart and skeletal muscle (PubMed:9427565). Highly expressed in testis (PubMed:9427565, PubMed:9662073). Detected in spleen, thymus, colon, ovary, small intestine, prostate and peripheral blood leukocytes (PubMed:9662073). Almost undetectable in liver and lung (PubMed:9662073).
亚细胞定位
Nucleus
关键词