TK2 O00142

线粒体胸苷激酶2 (EC 2.7.1.21) (2'-脱氧尿苷激酶 TK2) (EC 2.7.1.74) (脱氧胞苷激酶 TK2) (EC 2.7.1.-) (Mt-TK)

蛋白质信息 (UniProt)

线粒体胸苷激酶2 (EC 2.7.1.21) (2'-脱氧尿苷激酶 TK2) (EC 2.7.1.74) (脱氧胞苷激酶 TK2) (EC 2.7.1.-) (Mt-TK)

O00142

功能描述

在线粒体基质中磷酸化胸苷、脱氧胞苷和脱氧尿苷 (PubMed:11687801, PubMed:9989599)。在不分裂细胞中，细胞质dNTP合成下调，mtDNA合成完全依赖于TK2和DGUOK (PubMed:9989599)。广泛用作抗病毒和化疗药物的靶点 (PubMed:9989599)。 {ECO:0000269|PubMed:11687801, ECO:0000269|PubMed:9989599}。

组织特异性

Predominantly expressed in liver, pancreas, muscle, and brain.

亚细胞定位

Mitochondrion

关键词

Alternative splicing ATP-binding Direct protein sequencing Disease variant DNA synthesis Kinase Mitochondrion Nucleotide-binding Primary mitochondrial disease Progressive external ophthalmoplegia

外部链接

UniProt: O00142

NCBI Gene

GeneCards