TINCR A0A2R8Y7D0

含泛素结构域蛋白TINCR (胎盘特异性蛋白2) (终末分化诱导角质化调节因子) (pTINCR微蛋白)

功能描述

通过增强CDC42的SUMO化修饰和激活，促进上皮分化 (PubMed:36369429)。促进角质形成细胞增殖 (PubMed:32012357)。这通过在皮肤损伤后增强伤口愈合，有助于维持皮肤稳态 (By similarity)。在上皮肿瘤中作为肿瘤抑制因子发挥作用 (PubMed:36369429, PubMed:36899004)。 {ECO:0000250|UniProtKB:A0A1B0GRQ3, ECO:0000269|PubMed:32012357, ECO:0000269|PubMed:36369429, ECO:0000269|PubMed:36899004}。

组织特异性

Detected in the stratum corneum, the outermost layer of the epidermis (at protein level) (PubMed:32012357). Detected in skin, sweat and sebaceous glands (at protein level) (PubMed:36369429). Expressed in cutaneous basal keratinocytes with a prominent up-regulation in more differentiated spinocellular and granular skin layers (PubMed:36899004).

亚细胞定位

Nucleus